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Generic Copegus (Ribavirin)
Copegus is used to treat chronic hepatitis C which is a disease of the liver. It helps the immune system fight the hepatitis C virus, and make it harder for the virus to reproduce within the body.
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Copeguus In vitro resistance of hepatitis C virus Copegus ribavirin has been demonstrated, but clinical resistance to ribavirin remain poorly defined. Search for. View Older Articles. Do not freeze, shake, or use them past the expiry date. Heart disease. Contraindications: Hemoglobinopathies eg, thalassemia, sickle-cell anemia. Last updated Ribavirin causes hemolytic anemia. Copeguw Enrollment Coprgus. You Copegs to have a popup blocker enabled. Pegasys is contraindicated in patients with hypersensitivity to Pegasys or any of its components, autoimmune hepatitis, and decompensated hepatic disease prior to or during treatment with Pegasys. If you experience vomiting as a side effect of this medicine it is important to rinse out the mouth thoroughly afterwards. It is estimated that less than 30 percent of all cases are diagnosed. If psoriasis appears, the medication may need to be discontinued. Teeth and gum disorders, which may lead to loss of teeth, have been reported when this medicine is used in combination with interferon alfa or peginterferon alfa. In addition, ribavirin can cause severe anemia and dose adjustement is required in some patients who develop anemia. For general information, Learn About Clinical Studies. Weekly news roundup. It is given once-weekly by injection and compared to standard combination therapy, Pegasys is associated with a significant reduction in the incidence Copsgus certain side-effects such as flu-like symptoms, depression and hair loss. If you have depression or a history of depression, discuss with your Copegys how this medication Copegus affect your medical Coppegus, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Diagnosed Doctor Discussion Guide. COPEGUS is available only as a mg tablet and therefore the healthcare provider should determine if this sized tablet can be swallowed by the pediatric patient. Infection: Interferon alfa-2a can reduce the number of cells that fight infection in the body white blood cells. A side effect is an unwanted response to a medication when it is taken in normal doses. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe. Not to be used in People with severe heart diseaseparticularly if unstable or uncontrolled in the last six months. Your pharmacist may be able to advise you on managing side effects. Laboratory Values. In addition, ribavirin can cause severe anemia and dose adjustement is required in some patients who develop anemia. Table of Contents. This medication is usually injected under the skin subcutaneously in the abdomen or thigh area. If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible. Body weight in kilograms kg. Depending on your specific circumstances, your doctor may want you to:.

Copegus - apologise, but

Figure 4. Rochebased in Nutley, N. Laboratory Values. Monitor hepatic function during therapy. Tablets - Ribavirin Copegus. Copebus for 48 weeks Genotype 1, Copetus or 24 weeks Genotype 2, 3. In addition, ribavirin can cause severe anemia and dose adjustement is required in some patients who develop anemia. Concomitant didanosine. Do not dispose of medications in wastewater e. Bleeding: Interferon alfa-2a may cause a reduced number of platelets in the blood, which can make it difficult to stop cuts from bleeding. Drugs Viral infections. Transplants: The safety and effectiveness of this medication have not been established for people with hepatitis C infections who have had a liver or other organ transplant. Once Copegus has been withheld due to either a laboratory abnormality or clinical adverse reaction, an attempt may be made to restart Copegus at mg daily and further increase the dose to mg daily. In vitro studies indicate that ribavirin is not a substrate of CYP enzymes. It can be harmful for people to use this medication if their doctor has not prescribed it. The high molecular weight 40 kilodalton branched PEG in Pegasys has been shown to provide sustained pegylated interferon alfa-2a exposure at clinically effective levels over the one-week dosing period.

Copegus - agree, this

Routine monthly pregnancy test Co;egus be performed during this time. If you experience vomiting as a side effect of Coppegus medicine it is important to rinse out the mouth thoroughly afterwards. With peginterferon alfa-2a: autoimmune hepatitis, hepatic decompensation in cirrhotic patients before therapy. Risk of severe hemolytic anemia. Other less serious adverse effects have been observed with ribavirin, including fatigue, nausea, rash, and itching. Email Address. Patients in whom efficacy was demonstrated included patients with compensated liver disease and histological evidence of cirrhosis Child-Pugh class A. Your doctor may want to Copeugs your liver function regularly with blood tests while you are taking this medication. Treatment of chronic hepatitis Cin combination with either interferon alfa-2a Roferon-A or peginterferon alfa-2a Pegasys. Patients should be monitored closely with periodic clinical and laboratory evaluations. In both studies, virus genotype was clearly the strongest predictor of whether or not a patient achieved a sustained virological response. Start now. Use with caution in Decreased kidney function. Store the packages, vials, or prefilled syringes in the refrigerator, protect them from light, and keep them out of the reach of children. Breast-feeding: It is not known if peginterferon alfa-2a - ribavirin passes into breast milk. Concentration difficulties. Roche discovers, develops, manufactures and markets numerous important prescription drugs that enhance people's health, well-being and quality of life. Pegasys is currently available at pharmacies. If you have a thyroid condition, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention. This Copegus the amount of hepatitis C virus in the body and leads to a reduction in liver damage and Copwgus improvement in Copegys function. You should discuss this with your doctor before starting treatment. Copegsu sustained virological response rate in the Pegasys and Copegus treated patients was 53 percent compared to 44 percent in the interferon alfa- 2b and ribavirin group. Patients Copetus be monitored Colegus with periodic clinical and laboratory evaluations. Mortality nearly doubled when patients stopped using their drugs. This medication is not recommended for use by newborns or Copeguz because peginterferon alfa-2a contains benzyl alcohol and may be harmful. Ribavirin is genotoxic, mutagenic, and should be considered a potential carcinogen. Not to be used in People with severe heart diseaseparticularly if unstable or uncontrolled in the last six months. Women of childbearing potential and men: use 2 forms of effective contraception during and for 6 months following treatment. Figure 1. Pegasys is contraindicated in patients with hypersensitivity to Pegasys or any of its components, autoimmune hepatitis, and decompensated hepatic disease prior to or during treatment with Pegasys. Kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects. During this time, women will have monthly pregnancy tests to ensure they are not pregnant. Pegasys, a premixed solution, is dosed at mcg as a subcutaneous injection once a week. Type keyword s to search. Medications other than those listed above may interact with this medication. Transplants: The safety and effectiveness of this medication have not been established for people with hepatitis C infections who have had a liver or other organ transplant. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Common use

Copegus is used together with an interferon (such as PegIntron or Intron A) to treat chronic hepatitis C which is a disease of the liver. This is a drug for the patients who have not been treated with interferon previously or who have had a return of hepatitis C following successful treatment with interferon. It helps the immune system fight the hepatitis C virus, and make it harder for the virus to reproduce within the body. Copegus belongs to the antivirals.



Dosage and direction

The usual dose of Copegus per day is 800 mg, 1,000 mg, or 1,200 mg i orally in two divided doses (morning and evening) with food for 24 or 48 weeks. The dose and duration of treatment depend on your condition, on body weight, on baseline disease characteristics, response to therapy and tolerability of the regimen. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. It should be taken consistently. For example, it should be taken at the same time or times each day and each time.



Precautions

Copegus may decrease the number of red blood cells in your body (anemia) and it can be life-threatening in people who have heart disease or circulation problems. Careful consideration is advised if Copegus is used in patients with heart or circulation problems since the anemia may aggravate these conditions. Your blood will need to be tested often. Also your vision, liver function and thyroid function may also need to be tested. Visit your doctor regularly. Call your doctor at once if you have pale or yellowed skin, dark colored urine, fever, confusion, chest pain, weakness, or trouble breathing. Copegus may cause birth defects and/or death in unborn babies that are exposed to it during pregnancy. If you or your sexual partner are or may be pregnant, do not take Copegus, and contact your doctor immediately. Women and men who are taking Copegus must avoid pregnancy during treatment with this drug and for 6 months after this medication has been stopped. Consult your doctor or pharmacist for more information.



Contraindications

Before taking Copegus you should talk with your doctor if you are allergic to peginterferon alfa-2a, any other interferon, ribavirin, polyethylene glycol, or to any of the ingredients of the medication, if you are an infant, breast-feeding, pregnant or has a pregnant partner. Also in the way if you have decompensated liver disease, hemoglobinopathies (thalassemia, sickle-cell anemia), HIV-HCV (human immunodeficiency virus and hepatitis C virus) with cirrhosis and a baseline Child-Pugh score greater than or equal to 6. And you should discuss with your doctor if you have a severe psychiatric disorder, autoimmune diseases (including autoimmune hepatitis), thyroid problems not controlled by medication even in the past.



Possible side effects

The most common side effect of Copegus is a flu-like syndrome consisting of body aches and pains, fever, chills, headache and malaise. The most serious side effect is anemia. Patients with certain types of heart disease should not use Copegus. This may make your condition worse and can lead to a possibly fatal heart attack. Copegus should be avoided among patients who have severe kidney disease and have lost most of their kidneys' function. Therapy with Copegus and interferon may aggravate psychiatric conditions or may cause a psychiatric condition such as depression, suicidal ideation, psychosis, aggressive behavior, hallucinations, or violent behavior. Patients should be closely monitored for the development of these psychiatric conditions. Therapy has caused abnormalities of the thyroid gland. If these abnormalities persist and cannot be controlled by medication, it may be necessary to finish this therapy. Other possible side effects that may occur during therapy with Copegus are fatigue, weakness, nausea, anorexia, heartburn, insomnia, irritability, difficulty breathing, rash, itching, and alterations in taste perception.



Drug interactions

If Copegus is used with other antiviral drugs with similar mechanisms of action it may cause a condition in which lactic acid accumulates in the blood (lactic acidosis). This situation can lead to serious medical problems. Also do not take Copegus with antiviral drugs that used to manage HIV infection (zidovudine (Retrovir), zalcitabine (Hivid) or stavudine (Zerit)).



Missed dose

If you miss a dose of Copegus, take the missed dose as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.



Overdose

Overdose symptoms may include easy bruising or bleeding, urinating less than usual or not at all, chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, or a general ill feeling. If you experience something from list above you need emergency medical attention.



Storage

Store Copegus in the refrigerator, protect them from light, and keep them out of the reach of children. Do not freeze, shake, or use them past the expiry date.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
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