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Generic Daklinza (Daclatasvir )
Daklinza (daclatasvir) is an antiviral medicine that prevents hepatitis C virus (HCV) from multiplying in your body. Daklinza is used to treat genotype 1 and genotype 3 chronic hepatitis C in adults with or without cirrhosis.
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More on CHealth. Leave this field blank. An interaction between two medications does not always mean that you must stop taking one of them. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Galactose intolerance: Daclatasvir is prepared with lactose. Give a list of all your medicines to any healthcare provider who treats you. Tell your doctor about all medicines you use, and those you start or stop using during your treatment. We will not rent your email to anyone. Daklinza reviews. Concurrent use with amiodaronesofosbuvir and daclatasvir has may result in an increased risk for serious slowing of the heart rate. Retrieved 4 February Talk to your doctor about hepatitis C. Daklinza is the first week, all-oral therapy indicated for the treatment of Hepatitis C HCV genotype 3 infections. Cost, lack of coformulation, and the recommendation of baseline NS5A testing in genotype 1a cirrhotic patients make daclatasvir plus sofosbuvir a less compelling option in this subset of patients. If you have lactose or galactose intolerance you should not take this medication. Create a personalized discussion guide to use when talking with your doctor. The most common side effects when using Daklinza in combination with Sovaldi are fatigue, headache and nausea.

Daklinza - remarkable, very

Top 5 Milk Thistles Provides information Daklniza the best known milk thistle supplements. Patient Support Connect. Hepatitis C Online. NHS treatment. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. Myths: Pneumococcal disease. The latest news on hepatitis treatments, clinical trials, social issues and important breakthroughs. Geneva: World Health Organization. When taking daclatasvir with non-nucleoside reverse transcriptase inhibitorsthe dose of daclatasvir is increased to overcome CYP3A induction. How it works Daclatasvir, the active substance in Daklinza, blocks the action of a protein in the hepatitis C virus called NS5A which is essential for the virus to multiply. Information at this website is for educational purposes only. The latest HCV guidelines developed by the Infectious Diseases Society of America and the Daklinza Association for the Study of Liver Diseases include daclatasvir in their assemblage of recommended regimens for the treatment of the disease. Available at: www. Search form Search. MavyretHarvoniEpclusaribavirinVoseviSovaldi. Outcomes for patients without SVR Use this Search to quickly find items or navigate the site. Studies demonstrate that shorter-duration therapies are just as effective, if not more effective, in achieving acceptable SVR as the longer regimens used in the past. Enter Zip Code GoodRx. Daklinza daclatasvir prescribing information. In combination with sofosbuvir, with or without ribavirin, to treat chronic HCV genotype 1 or 3 infection. Recommended article. You should not stop using this medicine suddenly. Pharmaceutical Development Group. Concomitant amiodarone with daclatasvir in combination with sofosbuvir: not recommended; if no alternatives, monitor cardiac function. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Studies demonstrate that shorter-duration therapies are just as effective, if not more effective, in achieving acceptable SVR as the longer regimens used in the past. Information at this website is for educational purposes only. Liver Int. Daklinza is an antiviral medicine used in combination with other medicines to treat chronic hepatitis C. Food and Drug Administration. Ribavirin can cause birth defects or death in an unborn baby. The infection is less likely to exhibit symptoms until the liver gets damaged, which may take several years. If you take daclatasvir with sofosbuvir : There may be other reasons you should not take this combination treatment. Cirrhosis Many discussions and analyses of cirrhosis, including causes, complications, pathology, symptoms, and much more. Hepatitis C Alternative Therapies Alternative methods of treatment due to side effects and dissatisfication with current medical treatments.

Common use
The active ingredient present in is daclatasvir – 60 mg.
Daklinza is a drug for the treatment of hepatitis C (HCV). Daclatasvir inhibits the HCV nonstructural protein NS5A. Recent research suggests that it targets two steps of the viral replication process, enabling rapid decline of HCV RNA. Daklinza is indicated for use with sofosbuvir, with or without ribavirin, for the treatment of patients with chronic hepatitis C virus (HCV) genotype 1 or genotype 3 infections.
It is advised to avoid pregnancy during combination treatment with Daklinza and sofosbuvir with ribavirin for 6 months after completion of treatment.

Dosage and direction
The recommended dosage of Daklinza is 60 mg, taken orally, once daily, with or without food.
Recommended Treatment Regimen and Duration for Daklinza
Genotype 1:
Without cirrhosis - Daklinza + sofosbuvir for 12 weeks
Compensated (Child-Pugh A) cirrhosis - Daklinza + sofosbuvir for 12 weeks
Decompensated (Child-Pugh B or C) cirrhosis - Daklinza + sofosbuvir + ribavirin for 12 weeks
Post-transplant - Daklinza + sofosbuvir + ribavirin for 12 weeks
Genotype 3:
Without cirrhosis - Daklinza + sofosbuvir for 12 weeks
Compensated (Child-Pugh A) or decompensated (Child-Pugh B or C) cirrhosis - Daklinza + sofosbuvir + ribavirin for 12 weeks
Post-transplant - Daklinza + sofosbuvir + ribavirin for 12 weeks
For specific dosage recommendations for sofosbuvir, refer to the prescribing information.

Precautions
The concomitant use of Daklinza and other drugs may result in known or potentially significant drug interactions, some of which may lead to loss of therapeutic effect of Daklinza and possible development of resistance, dosage adjustments of concomitant medications or Daklinza, possible clinically significant adverse reactions from greater exposures of concomitant drugs or Daklinza.
Postmarketing cases of symptomatic bradycardia and cases requiring pacemaker intervention have been reported when amiodarone is coadministered with sofosbuvir in combination with another HCV direct-acting antiviral, including Daklinza. A fatal cardiac arrest was reported in a patient receiving a sofosbuvir-containing regimen (ledipasvir/sofosbuvir). Bradycardia generally resolved after discontinuation of HCV treatment. The mechanism for this bradycardia effect is unknown.
For patients taking amiodarone who have no alternative treatment options and who will be coadministered Daklinza and sofosbuvir need cardiac monitoring for the first 48 hours of coadministration, after which outpatient or self-monitoring of the heart rate should occur on a daily basis through at least the first 2 weeks of treatment.

Contraindications
Drugs that are Contraindicated with Daklinza:
Anticonvulsants - phenytoin, carbamazepine
Antimycobacterial agents - rifampin
Herbal products - St. John’s wort (Hypericum perforatum)

Possible side effect
Most common side effects occurred during the trials in combination with sofosbuvir (with or without ribavirin), with peginterferon alfa/ribavirin, with asunaprevir, or with asunaprevir/peginterferon alfa/ribavirin are such: fatigue, headache, pruritus, insomnia, influenza-like illness, dry skin, nausea, decreased appetite, alopecia, rash, asthenia, irritability, myalgia, anemia, pyrexia, cough, dyspnea, neutropenia, diarrhea, arthralgia, neutropenia, anemia, thrombocytopenia, and lymphopenia.
If you take Daklinza with sofosbuvir and you also take a heart rhythm medicine called amiodarone: This combination of medicines can cause dangerous side effects on your heart.

Drug interaction
Potential for Other Drugs to Affect Daklinza (clinically relevant increase in concentration):
HIV antiviral agents - Atazanavir with ritonavirb; Indinavir; Nelfinavir; Saquinavir
Other antiretrovirals - Cobicistat-containing antiretroviral regimens e.g. atazanavir/cobicistat,
elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate
Anticoagulants - Dabigatran etexilate mesylate
Strong inhibitors of CYP3A (eg, clarithromycin, itraconazole, ketoconazole, ritonavir) may increase the plasma levels of daclatasvir.
Potential for Daklinza to Affect Other Drugs (clinically relevant decrease in concentration):
Non-nucleoside reverse transcriptase inhibitors (NNRTI) - Efavirenzb; Etravirine; Nevirapine
Moderate CYP3A inducers (see also HIV antiviral agents) - Examples: bosentan, dexamethasone, modafinil,
nafcillin, rifapentine.
Daclatasvir is an inhibitor of P-glycoprotein transporter (P-gp), organic anion transporting polypeptide (OATP) 1B1 and 1B3, and breast cancer resistance protein (BCRP). Administration of Daklinza may increase systemic exposure to medicinal products that are substrates of P-gp, OATP 1B1 or 1B3, or BCRP, which could increase or prolong their therapeutic effect or adverse reactions.

Missed dose
Take Daklinza every day at the regularly scheduled time with or without food. It is important not to miss or skip doses and to take Daklinza for the duration that is recommended by the physician. For instructions for missed doses of other agents in the regimen, refer to the respective prescribing information.

Overdose
There is no known antidote for overdose of Daklinza. Treatment of overdose with Daklinza should consist of general supportive measures, including monitoring of vital signs and observation of the patient’s clinical status. Because daclatasvir is highly protein bound (>99%), dialysis is unlikely to significantly reduce plasma concentrations of the drug.

Storage
Store Daklinza tablets at 25°C (77°F), with excursions permitted between 15°C and 30°C (59°F and 86°F). Store away from moisture and heat. Keep all drugs out of the reach children and pets.

Disclaimer
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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