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Generic Detrol La (Tolterodine)
Detrol La is prescribed for treatment of spasms of the bladder muscles, overactive bladder characterized by symptoms of urinary urgency, frequency, and incontinence.
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Detrol La $67.00
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4mg
30pills
Detrol La $174.00
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4mg
60pills
Detrol La $320.00
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4mg
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4mg
120pills
Detrol La $535.00
$445.99
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The primary metabolic route involves the oxidation of the 5-methyl group and is mediated by the cytochrome P 2D6 CYP2D6 and leads to the formation of a pharmacologically Deetrol metabolite, 5-HMT. Overactive Detgol happens when you cannot control your bladder muscle. Detrol LA is a long-acting Detro drug that can help you manage your bladder muscle so there are less urgent signals that have you Detfol to find a restroom. This may contribute to greater patient satisfaction with treatment, resulting in patients staying on treatment longer. Know the medicines you take. Ask your doctor if there are risks with taking Detrol LA while you are pregnant, trying to become pregnant, or are breast feeding. The primary efficacy assessment was change in mean number of incontinence episodes per week at week 12 from baseline. Phase 4. We always guarantee you the lowest price. Detrol LA. Detrusor overactivity DO, contraction of the muscular bladder wall is the most common form of urinary incontinence UI in older adults. Tell your doctor about all medications you use. Disruption of daily activities was also shown to improve with DETROL LA across several health-related quality of life measures, including physical limitations, sleep and energy. Abnormal bladder contractions that coincide with the urge to void can be measured by urodynamic studies. Tell your doctor if you are pregnant or plan to Dettrol pregnant while using this medication. Mean C max Dehrol tolterodine immediate release 1. From Wikipedia, the free encyclopedia. Drug: Detrol LA. This means that less drug needs to be given daily due to efficient targeting of the bladder and so LLa are fewer side effects. Its structure is:. Lz D. In vivo drug-interaction data show that tolterodine immediate release does not result in clinically relevant inhibition of CYP1A2, 2D6, 2C9, 2C19, or 3A4 as evidenced by lack of influence on the marker drugs caffeine, debrisoquine, S-warfarin, and omeprazole. Detrol LA side effects in more detail. Detrol LA is a long-acting anticholinergic drug that can help you manage your bladder muscle so there are less urgent signals that have you scrambling to find a restroom. Fluoxetine, a potent inhibitor of CYP2D6 activity, significantly inhibited the metabolism of tolterodine immediate release in CYP2D6 extensive metabolizers, resulting in a 4. However, the confidence intervals overlapped. Outcome Measures. Both the 2 mg and 4 mg capsule strengths are imprinted with a pharmaceutical grade printing ink that contains shellac glaze, titanium dioxide, propylene glycol, and simethicone. Talk with your doctor and Laa members or friends about deciding to join a study. Phase 4. Retrieved 6 June Solubility Ethanol. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. The urge to urinate becomes almost desperate and you must get to a restroom immediately even though you know your bladder is not full. Drug Status Rx. Warning You have reached the maximum number of saved studies Detrol LA reduces spasms of the bladder muscles. Medically reviewed by Drugs. Detrol LA drug interactions in more detail. Upcoming Events 09 Sep. All rights reserved. Behavioral techniques such as pelvic floor muscle exercises, or bladder training may provide additional benefit to the medication by helping the patient reassert control over his or her bladder. Actual Primary Completion Date :. Tolterodine treatment improves storage symptoms suggestive of overactive bladder in men treated with alpha-blockers. Research Use Only. Inquiry for MBS Subscribe to Drugs. Skip to Content. Diphenidine Ephenidine Fluorolintane Methoxphenidine. Please refer to this study by its ClinicalTrials. IUPAC name. Detrol LA. Do not take in larger or smaller amounts or for longer than recommended. More Information.
Common use

Detrol La contains tolterodine tartrate, the substance of cholinergic (acetyl-choline) receptor blockers class. The medication is used to reduce spasms of the bladder muscles, overactive bladder with symptoms of urge urinary incontinence, and frequency.



Dosage and direction

Detrol La is taken two times a day. The recommended initial dose is 2mg taken twice daily. Treatment by long-acting Detrol La should be started by 4mg daily dose. If it is not well tolerated it should be reduced to 2mg. Dose adjustment is needed for the patients with impaired liver or kidney function. Do not open Detrol La capsules, do not crush or chew them. Swallow the tablet whole.



Precautions

Discuss with your doctor about following conditions you may have: glaucoma, kidney or liver disease, myasthenia gravis, or a personal or family history of "Long QT syndrome." This medicine may change your thinking reactions or ability to concentrate. Be careful while driving or operating machinery.



Contraindications

Detrol La cannot be used to treat patients with uncontrolled narrow-angle glaucoma, obstruction to the flow of urine (urinary retention), poor emptying of the stomach (gastric retention), allergic reaction to the components of the drug in history.



Possible side effect

Besides allergic reactions (hives, facial swelling, rash, skin eruptions, difficulty breathing) Detrol La may cause chest pain, fast or uneven heart rate, confusion, painful or difficult urination, hallucinations, urinating less than usual or not at all.



Drug interaction

Inform your doctor about all prescribed and over-the-counter medications you are using and especially about the drugs which may interfere with elimination of tolterodine by the liver which include: cyclosporine (Gengraf, Neoral, Sandimmune), clarithromycin (Biaxin), azithromycin (Zithromax), erythromycin, telithromycin (Ketek), pentamidine (NebuPent, Pentam), sparfloxacin (Zagam), itraconazole (Sporanox), ketoconazole (Nizoral), and miconazole (Monistat, Micatin), arsenic trioxide (Trisenox), chloroquine (Arelan) or halofantrine (Halfan), levomethadyl (Orlaam), or methadone (Dolophine, Methadose), vinblastine (Velban), medications used to treat psychiatric disorders such aschlorpromazine (Thorazine), mesoridazine (Serentil), pimozide (Orap), haloperidol (Haldol), or thioridazine (Mellaril), heart rhythm medicine such as disopyramide (Norpace), procainamide (Procan, Pronestyl), amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), sotalol (Betapace), quinidine (Cardioquin, Quinaglute).



Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.



Overdose

Symptoms of overdose include blurred vision, dry mouth, and fast heartbeat.



Storage

Store at room temperature 15-30 C (59-86 F) away from moisture and heat.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
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