Concise Prescribing Info. Glibenclamide belongs to a group of medicines called sulfonylureas. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. Do not take Glucovance if the packaging shows signs of tampering or the tablets do not look quite right. Your doctor may increase the dose slowly over one or two weeks, depending on your blood glucose levels and other tests. Taking Glucovance with miconazole may cause an excessive drop in your blood glucose level. Related Drugs. Glyburide-Metformin 2. If you do not understand the instructions on the pack, ask your doctor or pharmacist. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Taking additional metformin or glibenclamide-containing products may increase the risk of you getting unwanted side effects. Call your doctor immediately if you experience any of the symptoms listed in the Warning section or any of the following serious side effects:. If you do experience any signs of hypoglycaemia, raise your blood glucose quickly by eating jelly beans, sugar or honey, drinking a non-diet soft drink or taking glucose tablets. Subscribe to our newsletters. Use the medicine exactly as directed. How likely would you be to recommend Glucovance to a friend? Especially tell your doctor if you: are allergic to Glucovance or to any of its ingredients have kidney problems, other than diabetes have liver problems have heart problems have a G6PD deficiency have hormone disorders or are receiving hormone therapy have acute or chronic metabolic acidosis are pregnant or breastfeeding Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. In addition, patients should maintain a good diet and exercise program, as well as regular blood glucose monitoring. The drug may also increase the chance that you will become pregnant. Glycovance may not experience any of them. The drug may also increase the chance that you will become pregnant. Glucovance is Gluvovance only with a doctor's prescription. Pregnant women with gestational or Type 2 diabetes who require medication are placed in one of two groups: Insulin injections or Glucovanc oral administration. New Zealand. The mean final doses were 20 mg fixed dose for glyburide, mg for metformin, 8. Diabet Med ; Unless you are within 10 to 15 minutes of your next meal or snack, follow up with extra carbohydrates such as plain biscuits, fruit or milk. Second-line therapy of Type 2 DM. Glucovance is available only with a doctor's prescription. It may take up to two weeks before you experience its full benefits. Protect your skin when you are in the sun, especially between 10 am and 3 pm. This is the best way to tell if your diabetes is being controlled properly. You may develop lactic acidosis, a dangerous build-up of Glkcovance acid in your blood. Mechanism of Action. This will reduce Glucovanc chances of you having an upset stomach or a hypoglycaemic episode. Patients who give consent for participation will be randomly assigned to either insulin therapy Glucovance usual standard of careor to oral Glucovance therapy the experimental group. What is the medicines and poisons schedule? Translator Translate texts with the world's best machine translation technology, developed by the creators of Linguee. You may need different amounts of your medicines or you may need to take different medicines. Your doctor may suggest avoiding alcohol. Hepatic insufficiency, acute alcohol intoxication, alcoholism; porphyria. It is very important that you speak to your doctor immediately if a side effect is severe, occurred suddenly or gets worse rapidly. Store below 25 degrees Celsius Shelf lifetime is 3 Years. Take your medicine at about the same time each day. Choose one. How long to take it for Keep taking Glucovabce for as long as your doctor tells you to. Skip to Content. Elderly people The dose depends on the renal function. Glucovance Gluclvance. Rx Prescription medicine; supplied on prescription only. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Immediately telephone your doctor, or the Poisons Information Centre telephone 13 11 26 for advice, or go to Accident and Emergency at the nearest hospital, if you think you or anyone else may have taken too much Glucovance.
Glucovance - possible Signs may include:. Take Glucovance immediately before your meal. Your doctor Glycovance replace Glucovance with insulin while you are pregnant. Glucoovance you Glucovaance any concerns about taking this medicine, talk to Goucovance doctor or pharmacist. Manufacturer Back to Top. Some of the symptoms of an allergic reaction may include skin rash, itching or hives; swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing; wheezing or shortness of breath. In some cases, this may be harmful and Glucovancr doctor may advise you to avoid certain foods. Do not use any other medicines containing metformin or glibenclamide, in Glucovande form of either a single or a combination product, while you are being treated with Glucovance. If you become pregnant while taking Glucovance, tell your doctor. Serious side effects have been reported with Glucovance. If it's almost time for your next dose, skip the missed dose and continue on your regular schedule. If you have to be alert, for example driving, be careful not to let your blood glucose levels fall too low. Biguanides lower blood-sugar levels in three ways: decreasing the glucose produced by your liver; slowing absorption of sugar in the digestive system; and increasing the amount of sugar that muscle cells absorb. If you are not sure what to do or have any questions, ask your doctor or pharmacist. Your doctor may occasionally change your dose. The above list includes some of the milder side effects of Glucovance. Extreme tiredness Weakness or discomfort Unusual or unexpected stomach pain Decreased appetite Deep and rapid breathing or shortness of breath Dizziness Lightheadedness Fast or slow heart beat Flushing of the skin Muscle pain Feeling cold Hypoglycemia low blood sugar. You may have an increased chance of getting side effects. Continue to take Glucovance even if you feel well. When you are travelling, it is a good idea to: wear some form of identification e. Related Drugs. It's not known whether the medicine passes into breast milk or if it could harm a breastfeeding baby. This is not a complete Glucocance of side effects and others may occur. It's not known whether the medicine passes into breast Glucovannce or if Gulcovance could harm a breastfeeding baby. Open menu. Metformin may stimulate ovulation in a premenopausal woman and may Gluxovance the risk of unintended pregnancy. Hyperglycaemia If you notice the return of any symptoms of hyperglycaemia, contact your doctor immediately. Please contact your local Merck representative if you have any inquiries. It's used along with diet and exercise to help lower blood-sugar levels by people who have type 2 diabetes. If you take too much overdose Immediately telephone your doctor, or the Poisons Information Centre telephone 13 11 26 for advice, or go to Accident and Emergency at the nearest hospital, if you think you or anyone else may have taken too much Glucovance. Call your doctor immediately if you experience any of the symptoms listed in the Warning section or any of the following serious side effects:. Outcome Measures. If you have type 2 diabetes, your body doesn't make or use the hormone insulin normally, so it can't control the amount of sugar, or glucose, in the blood.
Glucovance is a combination of two orally taken drugs possessing a hyproglycemic effect which belong to two different groups: metformin and glibenclamide. Metformin belongs to biguanide class of substances and decreases blood levels of glucose by increasity susceptibility of peripheral tissues to action of insulin. Metmorfin decreases absorption of carbohydrates in gastrointestinal tract and inhibits synthesis of glucose in the liver. Glibenclamide is a derivate of sulfonylurea and acts stimulating secretion of insulin by ОІ-cells of the pancreas. It is used along with a diet and exercise program to to treat type 2 diabetes (non-insulin-dependent diabetes).
Dosage and direction
Take Glucovance twice daily with meals and full glass of water. Take it regularly and each time every day to get the best benefit from it.
Avoid drinking alcoholic beverages during treatment with this medication. Notify your doctor first than to take Glucovance if you have any kind of fever, thyroid gland diseases with functional disorders, hypofunction of the anterior pituitary or the adrenal cortex. Inform your physician if you are pregnant or breastfeeding before to take this drug and also if you have severe breathing problems (e.g., obstructive lung disease, severe asthma), thyroid disease, blood problems (e.g., anemia, vitamin B-12 deficiency).
Hypersensitivity to metformin, glyburide, or other derivatives of sulfonylurea, type 1 diabetes, diabetic ketoacidosis, diabetic precoma, diabetic coma, kidney failure or kidney dysfunction, severe conditions which may lead to kidney dysfunction (dehydration, severe infection, shock), acute or chronic diseases that are accompanied by hypoxia of tissues: cardiac or respiratory failure, recent myocardial infarction,
hepatic impairment, porphyria, pregnancy, breast-feeding, co-administration with miconazole (anti-fungal), infectious diseases, extensive surgery, trauma, extensive burns and other conditions requiring a therapy with insulin, abnormal liver function, chronic alcoholism, acute alcohol intoxication, lactic acidosis, usage 48 hours before and 48 hours after the radioisotope or radiological examinations with help of iodinated contrast agents, in patients over 60 y.o., or doing hard physical work (risk of lactic acidosis increases), low glucose diet.
The following side effects are most common and be rather severe to stop taking of the medication: swelling or rapid weight gain, nausea, vomiting, gas, bloating, diarrhea and loss of appetite. In case of lactic acidosis also get emergency medical help: shortness of breath, stomach pain, weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, feeling light-headed, and fainting. Allergic reaction is also possible: hives, swelling, rash.
Cimetidine (Tagamet) increases blood levels of Glucophage affecting its metabolism. Glucophage is not compatible with alcohol. Concomitant administration with indirect anticoagulants and Cimetidine should be done with cautiousness. Glucophage enhances metabolism of Furosemide. Derivatives of sulfonylurea, insulin, acarbose, inhibitors of MAO, ACE inhibitors (such as captopril), oxytetracycline, cyclophosphamide and salicylates increase the effects of Glucophage. Decrease of hypoglycemic effect of Glucophage is caused by co-administration with thyroid medicines, birth control pills and other hormones, Epinephrine, Glucagon, thiazide diuretics, nicotinic acid derivates. Azole antifungals (fluconazole) also interact with Glucovance.
If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.
Symptoms of Glucovance overdose are ones of low blood sugar: hunger, tremors, confusion, irritability, drowsiness, headache, weakness, sweating, fast heartbeat, seizure and have a source of sugar at hand always. If you experience one of them or any unusual symptoms call your doctor immediately.
Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.