Reglan - think already Pharmacologic Class: Dopamine-2 receptor antagonist. Reblan doses or long-term use can cause a serious movement disorder that may not be reversible. Renal or hepatic impairment. Robins Company Records, —". If severe symptoms are present, therapy should begin with IM or IV administration for up to 10 days until symptoms subside at which time the Reglzn can be switched to Reglan therapy. Enter Zip Code GoodRx. Treat for 2—8 weeks. By the s Swedish scientists identified a correlation of taking medications containing metoclopramide and the development of tardive dyskinesia, a typically incurable kind of movement disorder. Clin Pharmacol Ther. Explore now. They suggested its use in older children should be restricted to treating post-chemotherapy or post-surgery nausea and vomiting, and even then only for patients where other treatments have failed. Antagonists: Atypical antipsychotics e. Parenteral Nutrition. Like every medication, Reglan and other drugs containing metoclopramide have mild to severe side effects and adverse reactions in some individuals. From Wikipedia, the free encyclopedia. Side effects were usually seen in the first 15 min after the dose of metoclopramide. Call your doctor for medical advice about side effects. Australian Government. Metoclopramide-induced raised intracranial pressure. Resources for Trainees. It is Reglwn used in pregnancy as a second choice for treatment of hyperemesis gravidarum severe nausea and vomiting of pregnancy. Metoclopramide is commonly used to treat nausea Reglaj vomiting associated with conditions such as uremiaradiation sickness Regan, cancer and the effects of chemotherapyRevlaninfectionand emetogenic drugs. Metoclopramide may trigger anxiety and panic attacks. Make an appointment. Agonists: Alcohols e. This article has been cited by other articles in PMC. It should be used with caution in Parkinson's disease since, as a dopamine antagonist, it may worsen symptoms. This content does not have an Arabic version. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Keep the bottle closed tightly. Int J Case Reports Images. Chapter This site complies with the HONcode standard for trustworthy health information: verify here. What tips would you provide a friend before taking Reglan? Make an appointment. Be careful if you drive or do anything that requires you to be alert. Adult: Give 30mins before meals and at bedtime. Wyeth in the California state courts, the claims of the plaintiff against the generic companies Pliva, Teva, and Purepac that had sold the drugs RReglan the plaintiff actually took, and the Reylan against Wyeth, Rfglan product the plaintiff never took, were Regpan dismissed by the trial court, but the case was appealed, and in the appellate court upheld the dismissal of the cases against the generic companies, but reversed on Wyeth, allowing the case against Wyeth to proceed. That said, the agency is recommending that the drug only be prescribed to pregnant women when necessary. The Elephant Formulary. This list is not complete and there are many other drugs that can interact with metoclopramide. Do not take extra medicine to make up the missed dose. The first generics were introduced in In Conte v. Health Care Providers. World Health Organization model list of essential medicines: 21st list Common side effects include: feeling tired, diarrheaand feeling restless. This information does not replace the advice of a doctor. Rare but serious ADRs associated with metoclopramide therapy include agranulocytosissupraventricular tachycardiahyperaldosteronismneuroleptic malignant syndromeakathisia and tardive dyskinesia. Clinical Trials Information.
Reglan is an anti-vomiting medications which prevents vomit, hiccup, stimulates and coordinates motor activity of gastrointestinal tract. Reglan increases both acetylcholine release from neurons and cholinergic receptor sensitivity to acetylcholine. It is a blocker of serotonin receptors. It increases lower esophageal sphincter tone, stimulates contractions of smooth gastric muscles and at the same time relaxes the pylorus and duodenum. Reglan interacts with the dopamine receptors in the brain and can be effective in treating nausea. This medication is used to treat gastroesophageal reflux disease (GERD), diabetic gastroparesis, atonia and hypotonia of the stomach and intestines, biliary dyskinesia, flatulence, complex therapy of gastric and duodenal ulcers in phase of exacerbation, acceleration of peristaltic activity during gastrointestinal radiocontrast studies.
Dosage and direction
Usual dose of Reglan for adults is 5-10 mg 3-4 times a day before a meal with a glass of water. In patients with vomiting, severe nausea 10 mg of Reglan is administered intramuscularly (IM) or intravenously. Measure liquid drug with a special dose-measuring spoon. The oral concentrate form of Reglan must be mixed with another liquid (water, fruit juice, soda) or a soft food. Take this medication exactly as prescribed to you, do not use it longer than 3 months.
You should not take this medication if you are allergic to Reglan or have bleeding or blockage in your stomach or intestines, epilepsy or other seizure disorder, or an adrenal gland tumor. Notify your doctor about such your conditions as kidney or liver disease, congestive heart failure, diabetes, or a history of depression. Avoid drinking alcoholic beverages during treatment.
Bleeding in the gastrointestinal tract, mechanical intestinal obstruction, perforation of the stomach or intestines, pheochromocytoma, extrapyramidal disorders, epilepsy, prolactin-dependent tumors, glaucoma, pregnancy, breastfeeding, concomitant use of anticholinergic drugs, hypersensitivity to Reglan.
Possible side effect
Most common side effects of Reglan are drowsiness, restlessness, fatigue, anxiety, insomnia, depression, and sedation. More serious side effects include: tremors, rigidity, or restless muscle movements in your eyes, slow movements, tongue, jaw, or neck, mask-like appearance of the face (similar to Parkinson's disease), fever, stiff muscles, confusion, sweating, depressed mood, hallucinations, jaundice, swelling, tardive dyskinesia. Involuntary movements of the arms and legs are possible in children and adults over 30 y.o. If you experience symptoms listed above stop taking Reglan and notify your doctor about it, you may need immediate medical attention.
Narcotic pain medicine, sleeping pills, and medicine for anxiety can aggravate sleepiness caused by Reglan.
If you missed a dose take it as soon as you remember, but not if it is almost time of the next intake by your schedule. Skip the missed dose if it is almost time of your next dose. Do not try to compensate a missed dose by taking an extra one.
If you suspect that you took too much of the medication seek for immediate medical attention. Symptoms of overdose include drowsiness, confusion, tremors or uncontrolled muscle movements in face or neck, or seizure.
Save Reglan in a dry place away from sunlight at room temperature between 15-30 C (59-86 F).
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.