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Generic Seroquel (Quetiapine)
Seroquel is an oral antipsychotic drug to treat major depressive disorder, schizophrenia and bipolar disorder.
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180pills
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30pills
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Common Side Effects. As with some other anti-psychotics, quetiapine may lower the seizure threshold[37] and should be taken with caution in combination with drugs such as bupropion. Retrieved 3 April Antagonists: Adatanserin Agomelatine Atypical antipsychotics e. This finding is based on data of very limited quality. Antipsychotics N05A. A nucleophilic substitution is used to introduce the sidechain. Outcome Measures. Seroquel may impair your thinking or reactions. Archived from the original on 27 March Therapeutic Advances in Neurological Disorders. This finding is based on data of very limited Seroquel. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein. While you are taking quetiapine, you should avoid excessive exercise, stay inside as much as possible and dress lightly in hot weather, stay out of the sun, and drink plenty of fluids. Archived from the original on 10 February American Journal of Health-System Pharmacy. They are used in patients with schizophrenia, a mental illness with a number of symptoms, including disorganised thinking and speech, hallucinations hearing or seeing things that are not theresuspiciousness and delusions false beliefs. Children younger than 10 years of age should not normally take quetiapine, but in some cases, a doctor may decide that quetiapine is the best medication to treat a child's condition. It is also important information to carry with you in case of emergencies. Your doctor will probably tell you to start taking a low dose of the medication and gradually increase your dose as you did when you first started taking quetiapine. This can be harmful or prevent the drug from working well. You should not breast-feed while taking quetiapine. Symptoms of EPS include restlessness, tremor, and stiffness. In a comparison of 15 antipsychotics in effectiveness in treating schizophrenia, quetiapine demonstrated standard effectiveness. Acta Psychiatrica Scandinavica. Agonists: BRL Ergolines e. Share NAMI. Second generation antipsychotics SGAs increase the risk of diabetes, weight gain, high cholesterol, and high triglycerides. Liver via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine Seroquel [1]. Talk to your doctor about ways to control weight gain, such as eating a healthy, balanced diet and exercising. Leukopeniaa drop in white blood cell count, not as severe as agranulocytosis. Do not drive a car or operate machinery and take precautions to avoid falls until you know how this medication affects you. Hallucinations, disorganized thinking, and delusions may improve in the first weeks Sometimes these symptoms do not completely go away Motivation and desire to be around other people can take at least weeks to improve Symptoms continue to get better the longer you take quetiapine It may take months before you get the full benefit of quetiapine Summary of FDA Black Box Warnings Increased mortality in elderly patients with dementia-related psychosis Both first generation typical and second generation atypical antipsychotics are associated with an increased risk of mortality in elderly patients when used for dementia related psychosis. Archived from the original on 27 March Of the roughly 20 patients he saw that morning, four had been prescribed Seroquel, an antipsychotic, for insomnia. Seroquel By Psych Central Staff. Dialogues Clin Neurosci. Swallow quetiapine extended-release tablets whole; do not split, chew, or crush them. Talk to your doctor about your condition, symptoms, and personal and family medical history. Subscribe to Drugs. Taking it again could be fatal cause death. These findings are based on data of moderate quality. Many drugs can interact with quetiapine. Seroquel can cause a serious heart problem if you use certain medicines at the same time, including certain antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS. Seroquel reviews. Brand names. If any of these symptoms occur, contact your healthcare provider immediately. Symptoms include confusion, fever, Seeoquel muscle stiffness, and sweating. The European Commission issued a decision on 6 August Seroquek medication has not been studied in children to use for this purpose. Quetiapine may interact with other medications. Owing to Seroquwl risks associated with clozapine e. Be sure to mention any of the following: antidepressants; certain antifungals such as fluconazole Diflucanitraconazole Sporanoxketoconazole Nizoraland voriconazole Vfend ; antihistamines; barbiturates such as phenobarbital; carbamazepine Tegretol ; chlorpromazine; divalproex Depakote ; certain medications for irregular heartbeat such as amiodarone Cordaroneprocainamide, quinidine, and sotalol Betapace, Betapace AF, Sorine ; dopamine agonists such as bromocriptine Parlodelcabergoline Dostinexlevodopa Dopar, Larodopapergolide Permaxand ropinirole Requip ; erythromycin E. Seroquel is available as tablets 25, and mg while Seroquel XR is available as prolonged-release tablets 50, and mg. The consideration will be paid in cash and the proceeds used for general corporate purposes. Take as directed. The cost of these tests will depend on your insurance coverage. Ina young man named Dan Markingson committed suicide in a controversial Seroquel clinical trial at the University of Minnesota while under an involuntary commitment order. Quetiapine has the following pharmacological actions: [48] [49] [50] [51] [52] [53] [54] [55]. Namespaces Article Talk. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor when you are unable to seek treatment on your own. Explore Apps. Epub Jun Multiple lawsuits have been filed in relation to quetiapine's side-effects, in particular, diabetes. Seroquel you recommend this drug to others? Namespaces Article Talk. Symptoms of your condition that bother you the most If you have thoughts of suicide or harming Seeoquel Medications you have taken in the past for your condition, whether they were effective or caused any adverse effects If you ever had muscle stiffness, shaking, tardive dyskinesia, neuroleptic malignant syndrome, or weight gain caused by a medication If you experience side effects from your medications, discuss them with your provider. Placental exposure is least for quetiapine compared to other atypical antipsychotics. Your email address will not be published.
Common use

Seroquel is an oral antipsychotic (neuroleptic) medication used for treating schizophrenia and acute manic episodes associated with bipolar I disorder. It shows more affinity with serotonin receptors (5-HT2) than with dopamine receptors D1 and D2 in the brain. It also active toward the alpha 1 adrenoreceptor and less active toward alpha 2 adrenoreceptor. Duration of binding with 5-HT2-serotonin and D2 dopamine receptors is less than 12 hours. Mechanism of Quetiapine action is unknown. Though it is supposed that the therapeutic effect is mediated through a combination of dopamine type 2 (D2) and serotonin type 2 (5HT2) receptor antagonism. This medication is used to treat acute and chronic psychosis also ones in patients with schizophrenia.



Dosage and direction

Seroquel should be taken twice or thrice daily with or without food with a full glass of water. Swallo the tablet whole, do not crush or chew an extended-release tablet. Daily dose of four first therapeutic days is 50 mg, 100 mg (second day), 200 mg (third day), 300 mg (fourth day). Starting from the fourth day the dosage should be adjusted to the level of effective one (which can reach 750 mg daily). In patients with liver or kidney failure initial dose is 25 mg/day increased gradually by 25-50 mg till the effective dose is reached. Take exactly as prescribed by your physician and do not exceed the recommended dose.



Precautions

This medication affects ability to high concentration of attention so it may affect your ability to drive a car or operate machinery. Before to take Seroquel notify your doctor if you have liver or kidney disease, heart disease, high blood pressure, heart rhythm problems, heart attack or stroke in history, a history of low white blood cell counts, a thyroid disorder, high cholesterol or triglycerides, a personal or family history of diabetes, trouble swallowing, as you may need your dosage to be adjusted or pass special safety tests for this medication.



Contraindications

Hypersensitivity, pregnancy, breastfeeding. Seroquel should be used with cautiousness in patients with hypotension, epilepsy and epileptic seizures in history. Seroquel may contribute to development of heart failure, pneumonia, sudden death, in older adults with conditions caused by dementia.



Possible side effect

Seroquel antagonism of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug. Most common and frequent adverse effects of Seroquel are headache, agitation, dizziness, drowsiness, weight gain and stomach upset. Long term use of this medication may cause irreversible tardive dyskinesia, a neurologic disease which consists of involuntary movements of the jaw, lips, and tongue. Other side effects concern nervous system: headache, anxiety, fatigue, hostility, agitation, insomnia, tremors, convulsions, depression, neuroleptic malignant syndrome (hyperthermia, muscle rigidity, altered mental status, the lability of the autonomic nervous system increased activity of CPK). Adverse effects of Quetiapine for cardiovascular system are: tachycardia, prolongation of the interval QT. Dryness of the oral mucosa, nausea, vomiting, abdominal pain, diarrhea or constipation, increased activity of "liver" transaminases, pharyngitis, rhinitis may also appear. Allergic reactions such as skin rash, eosinophilia are also not excluded.



Drug interaction

Phenytoin (Dilantin) and thioridazine (Mellaril) decrease absorption of Seroquel in intestines and decrease its effects. Seroquel interacts with narcotic pain relievers, medications for hypertension interact with and their activities add: oxycodone and acetaminophen (Percocet, Roxicet, Tylox, Endocet), barbiturates, alprazolam (Xanax), clonazepam (Klonopin), ethanol, prazosin (Minipress) and terazosin (Hytrin). Toxicity of Quetiapine may increase if it is co-administered with the drugs able to influence work of cytochrome P450 which is responsible for metabolism of Seroquel, these drugs are: ketoconazole (Nizoral), itraconazole (Sporanox), fluconazole (Diflucan), erythromycin, clarithromycin (Biaxin), nefazodone (Serzone), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem, Tiazac, Dilacor).



Missed dose

Take the missed dose as soon as you remember. If it is almost time of your next dose just skip the missed dose and return to your schedule. Do not double dose this medication to make up the missed dose.



Overdose

If you took too much of Seroquel you may experience such symptomes: extreme drowsiness, fast heart rate, feeling light-headed, or fainting. If you suppose that took too much for this medication seek for immediate medical help.



Storage

Store Seroquel at room temperature, 15-30 C (59-86 F) away from sunlight, moisture, children and pets.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
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