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Generic Zetia (Ezetimibe)
Zetia is used to treat high cholesterol in combination with low fat diet.
Select Doses: 10mg
Zetia $60.00
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Zehia we tried to prevent miscarriages we gave pregnant women certain hormones, only to find out that their daughters years later had certain cancers. Patients who underwent LDL Zegia apheresis may have had an additive effect Zdtia LDL cholesterol reduction when compared with patients who did not undergo LDL cholesterol apheresis. Zetia and safety of ezetimibe added to ongoing statin therapy for treatment of patients with primary hypercholesterolemia. Vasc Health Risk Manag. Ezetimibe's mechanism of action involves reducing blood cholesterol by inhibiting the absorption of cholesterol in the small intestine. Drug Facts and Comparisons. Secondary endpoints included cholesterol synthesis, sterol excretion, and plasma concentrations of cholesterol and non-cholesterol sterols. Ezetimbe was approved by the FDA in as an alternative to statins and marketed under the brand name Zetia. Harlan Krumholz, a cardiologist at Yale, when told about the previously undisclosed studies. No dosage adjustment is needed in patients with mild hepatic insufficiency. Vytorin was developed as a combination of Zetia and Zocor, which was intended to enhance Zocor's cholesterol-fighting properties. Ezetimibe vs placebo Dujovne et al performed a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of ezetimibe 10 mg in patients with primary hyper-cholesterolemia. Journal of Chromatography B. There's also some evidence, so far inconclusive, that Vytorin-like combinations cause more muscle problems than Zocor or Zetia alone. Articles from Proceedings Baylor University. This can be harmful or prevent the drug from working well. Anthony DeMaria, a leading cardiologist who is also the editor in chief of the Journal of the American College of Cardiology. But before the drug was approved inone F. It has been associated with elevated levels of low-density lipoprotein LDL cholesterol and reduced levels of high-density lipoprotein HDL cholesterol. Do not take extra medicine to make up the missed dose. I accept the Terms and Privacy Policy. Not all possible interactions are listed in this medication guide. Vasc Health Risk Manag. If you take Zetia with another cholesterol medicine, follow your doctor's dosing instructions very carefully. Ezetimibe vs placebo Dujovne et al performed a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of ezetimibe 10 mg in patients with primary hyper-cholesterolemia. Also, the combination of ezetimibe and lovastatin has no greater adverse effects than lovastatin monotherapy 7. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient.

Zetia - thanks

The reduction in LDL cholesterol in the ezetimibe plus statin 80 mg group was In addition, the study presented pooled instead of individual baseline results but individual endpoint results. Drug Information Pharmacist Katie L. Therefore, drugs should be given only if the potential benefits justify the potential risk to the fetus. Subscribers only Sign in or Subscribe now. So, ezetimibe is indicated in pregnant women only if the potential benefit outweighs the risk to the fetus. I had a heart attack and have been put on many medications. Retrieved 3 March Duration of statin therapy prior to the addition of ezetimibe may have an effect on LDL cholesterol reduction. I still suffer from pain. To obtain a greater effect, ezetimibe may be given with a statin. Patients with homozygous familial hypercholesterolemia have a genetic deficiency of LDL cholesterol receptors, impairing their ability to clear LDL cholesterol from the blood. The primary efficacy variable was the percentage change of LDL cholesterol from baseline to endpoint. The Effects of Statins on Inflammation. Thus, more studies of ezetimibe in patients with secondary hypercholesterolemia would be beneficial. Maximal effect was seen at week 2 Zetiq was maintained throughout the 8-week treatment period. If you miss a dose, take it as soon as you remember. Zetia side effects in more detail. Therapeutic lifestyle changes include dietary changes, weight reduction, and increased physical activity. Through Zeta prescription medicines, vaccines, biologic therapies and animal health products, we work with customers and operate in more Zdtia countries to deliver innovative health Zeti. It belongs to a class Zetua lipid-lowering compounds that selectively inhibits the intestinal absorption of cholesterol and related phytosterols. Merck is reviewing the letter and will determine next steps. You should not use Zetia if you have moderate to severe liver disease. Ezetimibe has been demonstrated to cross the placenta when given to pregnant rats and rabbits in multiple oral doses. There has been minimal evidence of oxidative metabolism or phase I reaction in all species involved. It is not known whether Zetia alone will harm an unborn baby. For those patients who are at high risk of coronary heart disease, LDL cholesterol—lowering drug therapy may be essential. Pharmaceutical Press. Or they take it in a single pill, Vytorin, that combines Zetia with Zocor. This article has been cited by other articles in PMC. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. My latest try is Zetia. A review found that ezetimibe used as sole treatment slightly lowered plasma levels of lipoprotein abut the effect was not large enough to be important. This may lead to incomplete or biased data. The company assumes no duty to update the information to reflect subsequent developments. Therefore, ezetimibe should not be used in nursing mothers unless the benefit clearly outweighs the risk. PDF Print. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Zetia may be used alone or in combination with other cholesterol-lowering drugs. A cholesterol panel should be drawn to monitor the effectiveness of ezetimibe therapy. An overdose of Zetia should not produce life-threatening symptoms, but seek emergency medical help if you think you have overdosed. Does it work as effectively for heart attack prevention? Liver tests should be performed especially when Zetia is added to a statin therapy. Ezetimibe may have significant medication interactions with ciclosporin and with fibrates other than fenofibrate. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications, particularly before taking any action. July Skip the dose if it is almost time for your next dose. Take the case of the drug torcetrapib. A: Cholesterol comes from two main sources, dietary cholesterol in the food that we eat and the cholesterol that is produced by our bodies. A: Numbness and pinprick-like pain could be a side effect of Zetia Ezetimibewhich you are taking. Some of the side effects that can occur with Zetia include diarrhea, fatigue, and joint pain. If you miss a dose, take it as soon as you remember. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition. From Wikipedia, the free encyclopedia. Ezetimbe and statins are generally well-tolerated. Ezetimibe is metabolized mainly in the small intestine and liver via glucuronide conjugation, with subsequent biliary and renal excretion. Doses that high have been tested in clinical trials. Zetla J. The information on this page has been compiled for use by healthcare Zetai and consumers in the United States and therefore neither Everyday Zetiia or its licensor warrant that uses outside of the United States are appropriate, ZZetia specifically indicated otherwise. Every effort has Zdtia made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no guarantee is made to that effect. This can be harmful or prevent the drug from working well. Talk to your doctor about other drug options that may work for you. So to avoid high doses, doctors have combined low or average doses of statins with other agents, including fibrates such as gemfibrozil Lopid or fenofibrate TriCor ; niacin, which is one of the B vitamins vitamin B3, to be exact ; and colesevelam Welchola bile sequestrant. Find articles by Valerie Sheehan. Zetia only focuses on the cholesterol that you eat and decreases what is absorbed in the intestine. Therefore, drugs should be given only if the potential benefits justify the potential risk to the fetus. Treatment should address both diet and pharmacological therapy regimens. Gemfibrozil Lopid or cyclosporine Neoral can increase blood levels of Zetia, so watch for side effects if taken together. It seems as if they keep moving the "bad" LDL cholesterol goal line so it's harder to reach. Mobile Get Ratings on the go and compare while you shop Learn more. Such drugs include hydroxymethylglutaryl coenzyme A reductase inhibitors statinsbile acid sequestrants, nicotinic acid, and fibric acids. Subscribers only Sign in or Subscribe now! Ezetimibe 10 mg or placebo was administered daily for a period of 12 weeks. Get emergency medical help if you have signs of an allergic reaction to Zetia: hives; difficult breathing; swelling of Zehia face, Zstia, tongue, or throat. This may lead to a heart attack or stroke. Ezetimibe Zteia down, a recipient of the one-two punch, and the referee has begun his slow count: one, two, three …. If you take Zetia with another cholesterol medicine, follow your doctor's dosing instructions very carefully. The decision was made to release the results of the primary end point because of the growing level of scientific interest with the results. Inwhen Merck's brand of simvastatinknown as Zocor, was about to go off patent, Merck teamed up with Schering-Plough to produce a new patented product called Vytorin, a combination of simvastatin and Zetia. Thus, the utilization of statins will not increase LDL cholesterol receptors but just delay the process of cholesterol synthesis. It is well known that the adverse effects associated with statins, such as myopathy, rhabdomyolysis and elevated LFTs are dose dependent. This means you may need to take it with other cholesterol-lowering medications. I accept the Terms and Privacy Policy. All of the clinical trials that have been conducted apply to patients with primary hypercholesterolemia. Taylor pulled no punches at a press conference to discuss the results, pressing the point that at time when the nation is watching the bottom line on healthcare costs, it's time to switch to niacin -- which even in the branded formulation called Niaspan, which was used in the trial, is cheaper than Zetia. It also does not have an effect on the statin bioavailability. Ezetimibe is a therapeutically beneficial drug that works by a unique mechanism and differs from traditional lipid lowering therapies.
Common use

Zetia is an antihyperlipidemic agent which used for treating high blood cholesterol along with a low-fat, low-cholesterol diet. Also it is used to treat high blood sitosterol and campesterol along with diet therapy. Heart disease or heart attacks arent prevented by Zetia as tests show.

Dosage and direction

Take this medication orally with or without food/milk. The recommended Zetia dose is 10 mg once daily. Patients who require a larger reduction in LDL-C (over 55%) may be started at 10-40 mg once daily.

Note: this instruction presented here just for review. It's very necessary to consult with your doctor before using. It help you to get best results.


Do not use it without doctor permission. Be careful if you have specific medical conditions then this medicine should not be taken along with statins. This is especially true if you have liver disease or are pregnant or intend to get pregnant. If you are pregnant this drug should only be taken if it is absolutely necessary. If you drink large quantities of alcohol you should be closely monitored by their doctor while they are taking this medication.


Not allowed in people who are hypersensitivity to any component of this medication. The combination of Zetia with an HMG-CoA reductase inhibitor is not allowed in patients with active liver disease or unexplained persistent elevations in serum transaminases. All HMG-CoA reductase inhibitors are not allowed in pregnant and nursing women. Myopathy and rhabdomyolysis.

Possible side effect

They may include all types of an allergic reactions. Also the most possible side effects include:

unusual muscle weakness, tenderness, or pain;

loss of appetite, nausea, clay-colored stools, stomach pain, low fever, dark urine, jaundice;

chest pain;


fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.

Less serious include:

numbness or tingly feeling;

mild stomach pain, diarrhea;

tired feeling;



depressed mood;

runny or stuffy nose, cold symptoms;

joint pain, back pain; or


If you experience one of them stop using Zetia and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction

Zetia interact with the following medications: cholestyramine (Prevalite, Questran); colestipol (Colestid); colesevelam (Welchol); gemfibrozil (Lopid); cyclosporine (Neoral, Sandimmune, Gengraf); or a blood thinner such as warfarin (Coumadin).

Also note that interaction between two medications does not always mean that you

must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.


Symptoms of Zetia overdose are not known but it can be harmful.

If you experience one of them call your doctor immediately.


Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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